VEGF signaling pathway

Explore VEGF signaling pathways and find reagents for your next experiment.

VEGF signaling plays a key role in the formation and growth of blood vessels. It is induced by the binding of VEGF ligands to their cognate membrane-bound receptors, upon which multiple downstream pathways are activated.

These include the Ras/MAPK pathway to regulate cell proliferation and gene expression, the FAK/paxillin pathway involved in the rearrangement of the cytoskeleton, the PI3K/AKT pathway regulating cell survival, the PLCγ pathway, which controls vascular permeability, and many others.

  • For a complete guide to VEGF and angiogeneis products visit our VEGF portfolio.